Myocardial protective effects of pretreatment with captopril on ischemia-reperfusion myocardium in rabbits / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 211-214, 2005.
Article
em Zh
| WPRIM
| ID: wpr-813401
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the effect of pretreatment with captopril on myocardium ischemia-reperfusion injury in atherosclerotic rabbits.@*METHODS@#Thirty-two New Zealand white rabbits were assigned randomly to the normally feed group, cholesterol-feed (CF) group, and cholesterol food plus captopril group (cap-feed group), which were fed for 10 weeks. We examined the changes in the size of the infarct and changes in the myocardium ultrastructure resulting from coronary ischemia/reperfusion. Levels of endothelin (ET) and nitic oxide (NO) were measured in the different experiment stages.@*RESULTS@#The ET levels significantly increased and the content of NO significantly decreased in the CF group compared with those of the cap-feed group. The ultrastructure of myocardium cell was slightly destroyed and the infarct size was significantly smaller in the cap-feed group than the normally feed rabbits and CF rabbits.@*CONCLUSION@#The long-term captopril treatment can lighten the severity of myocardial injury produced by coronary ischemia/reperfusion.
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Sangue
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Captopril
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Traumatismo por Reperfusão Miocárdica
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Distribuição Aleatória
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Endotelinas
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Usos Terapêuticos
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Tratamento Farmacológico
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Infarto do Miocárdio
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Miocárdio
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2005
Tipo de documento:
Article