Effect of cyclosporine and simulect mono and combination therapy on cardiac allo-transplantation in rats / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To observe the effect of cyclosporine and simulect mono or combination therapy on cardiac allo-transplantation in rats.@*METHODS@#Recipients with allografts were treated with different doses of cyclosporine and/or simulect after cardiac allo-transplantation. Graft survival time was observed; the histopathological examination of graft tissues was performed; and levels of serum IL-2 and IL-4 were determined.@*RESULTS@#Mono or combination therapy with cyclosporine and/or simulect increased the survival of cardiac allografts. With the prolongation of survival time of the grafts, the rejection of grafts was moderated. The serum IL-2 level increased in acute rejected grafts; the serum IL-4 level increased evidently in long survival grafts.@*CONCLUSION@#Cyclosporine and simulect have an effect in the prolongation of cardiac allograft survival in rats, and the combination therapy shows an evident synergistic effect.