MICA*008/A5.1 allele and HCMV infection in kidney transplanted donees of Hunan Han nationality / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 479-482, 2006.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-813667
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the relationship between MICA*008/A5.1 allele and human cytomegalovirus (HCMV) infection in kidney transplanted donees of Hunan Han nationality.@*METHODS@#The MICA*008/A5.1 allele based on 91 kidney transplanted donees and 81 unrelated normal individuals of Han nationality in Hunan Province were analyzed by PCR/SSP assay. At the same time, anti-HCMV antibody IgM was detected in the serum by ELISA method.@*RESULTS@#The positive rate of MICA*008/A5.1 allele was significantly higher in the control group (56.79%) than that in the kidney transplanted donee group (34.07%) (P <0.05). The infection rate of HCMV in those individuals whose genotype was MICA*008/A5.1 (-) was significantly higher than that in the MICA*008/A5.1(+).@*CONCLUSION@#The individual whose genotype is MICA*008/A5.1 (+) is not liable to HCMV infection, but the individual whose genotype is MICA*008/A5.1 (-) is liable to HCMV infection.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sangue
/
Imunoglobulina M
/
Antígenos de Histocompatibilidade Classe I
/
China
/
Transplante de Rim
/
Infecções por Citomegalovirus
/
Citomegalovirus
/
Alelos
/
Genética
/
Genótipo
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2006
Tipo de documento:
Artigo