Inhibitory effect of quercetin on cervix cancer in mice / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 890-894, 2007.
Article
em Zh
| WPRIM
| ID: wpr-813781
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the antitumor effect and mechanism of quercetin on murine cervical carcinoma U14.@*METHODS@#The 615-strain mice with U14 cervical cancer cells were randomly divided into 4 groups: a control, a low-dose intervention group [1.5 g/(kg . d)], a middle-dose intervention group [3.0 g/(kg . d)], and a high-dose intervention group [6.0 g/(kg . d)]. Different treatments were inoculated intraperitoneally after 6 days of transplantation and all mice were sacrificed after 26 days. The weight of tumors and inhibitory rates were measured. The expression levels of microvessel density (MVD) and nuclear factor-kappaB (NF-kappaB) were detected by immunohistochemistry. The apoptosis index (AI) was measured by terminal deoxynucleotidyl transferase assay in situ (TUNEL).@*RESULTS@#Compared with the control group, the tumor growth in the high-dose intervention group was suppressed significantly, and the weight and volume of the tumor were markedly decreased (P0.05).@*CONCLUSION@#Quercetin showed a marked inhibitive effect on U14 growth, and its antitumor mechanism may be associated with inhibiting the angiogenesis and inducing apoptosis.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
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Farmacologia
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Quercetina
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Neoplasias do Colo do Útero
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Apoptose
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Ensaios Antitumorais Modelo de Xenoenxerto
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Linhagem Celular Tumoral
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Usos Terapêuticos
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Camundongos Endogâmicos
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Neovascularização Patológica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2007
Tipo de documento:
Article