Antibiotic resistance of Helicobacter pylori / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 447-450, 2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-813863
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To examine the infection and bacteria resistance of Helicobacter pylori (H.pylori) to clarithromycin and furazolidone,to determine whether the antibiotic resistance is primary or secondary, and to decide if a new H.pylori infection plays a role in eradication failures.@*METHODS@#Twenty one H.pylori had been isolated from human biopsy specimens, and antimicrobial susceptibility testing was performed. DNA fingerprints were generated using random amplification polymorphic DNA (RAPD) to determine the identity of H.pylori before and after the eradication therapy.@*RESULTS@#Eight bacteria resisted against clarithromycin, and one against furazolidone, with the resistant rates 38.1% and 4.8% respectively. The number of primary antibiotic resistance, secondary resistance and new infection was 1 for each.@*CONCLUSION@#Resistance to clarithromycin is more common compared with that to furazolidone. Development of primary and secondary resistance to clarithromycin occurs as a rule in eradication failures. New H.pylori infection plays a role in eradication failures.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
DNA Bacteriano
/
Testes de Sensibilidade Microbiana
/
Impressões Digitais de DNA
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Claritromicina
/
Técnica de Amplificação ao Acaso de DNA Polimórfico
/
Farmacorresistência Bacteriana
/
Usos Terapêuticos
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2007
Tipo de documento:
Artigo