Genomic instability in nasopharyngeal carcinoma / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 417-421, 2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-813869
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To evaluate the effect of genomic instability on prognostics in nasopharyngeal carcinoma.@*METHODS@#Genomic instability was assessed by inter-simple sequence repeats polymerase chain reaction (inter-SSR PCR) in 38 patients with nasopharyngeal carcinoma. Characterization and verification of band alterations shared in different tumors were carried out by sequencing and nest PCR.@*RESULTS@#Thirty-one (81.6%) of the 38 patients showed genomic altercations, and genomic instability index ranged 0 to 16.2 percent. A gain-based genomic damage shared in 6 tumors was identified on chromosome 6q27. Genomic alteration was significantly more in patients less than 5-year survival than those with more than 5-year survival (P<0.05).@*CONCLUSION@#Genomic instability can be an early event marker in carcinogenesis of nasopharyngeal carcinoma. Aggravation of genomic alterations is a poor prognosis for cancer recovery.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
/
Cromossomos Humanos Par 3
/
Cromossomos Humanos Par 6
/
Análise Mutacional de DNA
/
Dados de Sequência Molecular
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Sequência de Bases
/
Análise de Sobrevida
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Neoplasias Nasofaríngeas
/
Reação em Cadeia da Polimerase
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2007
Tipo de documento:
Artigo