Treatment of brain injured rats through transplanting amniotic-derived mesenchymal stem cells in different ways / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To compare the behavioral improvement to find the best transplantation approach for treating brain injury through transplanting amniotic-derived mesenchymal stem cells into brain injured rats in different ways.@*METHODS@#Eighty brain injured Wista rats were randomly divided into a control group with brain injury alone (n=20) and a treatment group(n=60) which were further evenly divided into Group A (transplanted through the vena caudalis), Group B (transplanted through the ventriculus cerebri lateralis), and Group C (transplanted through the injured brain area). Each group was transplanted with amniotic-derived esenchymal stem cells, and their therapeutic efficacy would be evaluated through the neurological severity score (NSS).@*RESULTS@#Compared with other groups, the behaviors of Group C had markedly improved. There was statistically significant difference in the 2 groups (P0.05).@*CONCLUSION@#Transplanting the amniotic-derived mesenchymal stem cells into the injured brain area may be effective for brain injury in rats.