Expression of HSP70/HSP27 protein in residual lesion after NPC radiotherapy / 中南大学学报(医学版)

ABSTRACT

OBJECTIVE@#To analyze HSP70/HSP27 protein expression in the nasopharyngeal carcinoma (NPC) primary tissues and the residual lesion, and to explore its predictive value.@*METHODS@#Immunohistochemical experiment was performed to detect the expression of HSP70 and HSP27 in 58 NPC primary tissues 28 were in the experimental group with the local residual lesion and 30 in the control group without recurring and metastasis within 5 years by conventional radiotherapy.@*RESULTS@#The positive expression of HSP70 and HSP27 in the experimental group was 92.9%(26/28) and 53.6%(15/28), while that in the control group was 53.3%(16/30) and 53.3%(16/30),respectively. There was significant difference in the 2 groups. The common positive expression of HSP70 and HSP27 between the 2 groups had significant difference, 50.0% (14/28) in the experimental group and 16.7% (5/30) in the control group, respectively. There was no significant difference in the negative ratio of HSP70 and HSP27 common expression between the 2 groups, 3.6% (1/28) in the experimental group and 10.0% (3/30) in the control group, respectively.@*CONCLUSION@#HSP70 may have an important role in the radioresistance of NPC, and may predict the residual lesion after radiotherapy.