Sex difference in performance in elevated plus maze and hippocampal GluR1 level / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 750-753, 2011.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-814528
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To explore whether sex difference exists in the performance in each arm of elevated plus maze (EPM) and GluR1 level in the hippocampus of female and male Sprague-Dawley rats.@*METHODS@#Eleven male and 10 female SD rats were tested for 5 minutes in the EPM. These rats were decapitated 30 min after testing. The left and right hippocampus were dissected. Samples were stored at -80 degree for protein extracting. Western blot was used to detect the GluR1 levels in the hippocampus.@*RESULTS@#Female rats exhibited less anxiety-like behaviors than male rats in the EPM (P<0.05).Female rats had lower GluR1 levels in total and left hippocampus than those of male rats (P<0.05).@*CONCLUSION@#Sex difference exists between female and male rats in the EPM and hippocampal GluR1.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ansiedade
/
Fisiologia
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Comportamento Animal
/
Caracteres Sexuais
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Ratos Sprague-Dawley
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Receptores de AMPA
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Aprendizagem em Labirinto
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Hipocampo
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Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2011
Tipo de documento:
Artigo