T-SPOT.TB in the diagnosis of tuberculous peritonitis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 526-531, 2013.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-814852
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To evaluate the value of T-SPOT.TB in the diagnosis of tuberculous peritonitis (TBP).@*METHODS@#A total of 50 patients with clinically suspected TBP admitted from August 2011 to July 2012 from the Third Xiangya Hospital were enrolled in this prospective cohort study. Peripheral blood T-SPOT.TB, purified protein derivatives of tuberculin (PPD) skin test, serum tuberculosis antibody (TB-Ab) and ascitic adenosine deaminase (ADA) were measured in the 50 patients and we compared the diagnostic value of the 4 methods.@*RESULTS@#According to the standard of diagnosis of TBP and grouping, 24 patients were diagnosed with TBP, 17 non-TBP and 9 undiagnosed in the end. The sensitivity of T-SPOT.TB for the diagnosis of TBP was 91.7% (22/24), with statistical significance when compared with PPD skin test 37.5% (9/24), serum TB-Ab 16.7% (4/24), and ascitic ADA 36.4% (8/22) (P0.05). The positive prediction value of T-SPOT.TB for the diagnosis of TBP was 84.6% (22/26), without statistical significance when compared with PPD skin test 75.0% (9/12), serum TB-Ab 57.1% (4/7), and ascitic ADA 100%(8/8) (P>0.05). The negative prediction value of T-SPOT.TB for the identification of non-TBP was 86.7% (13/15), with statistical significance when compared with PPD skin test 31.8% (7/22), serum TB-Ab 35.5% (11/31), and ascitic ADA 50.0% (14/28) (P<0.05).@*CONCLUSION@#Peripheral blood T-SPOT.TB for the diagnosis of TBP is highly sensitive, which is better than PPD skin test, serum TB-Ab, and ascitic ADA. T-SPOT.TB has an important reference for diagnosing suspected TBP quickly and accurately.
Texto completo:
Disponível
Contexto em Saúde:
Doenças Negligenciadas
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Doenças Negligenciadas
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Tuberculose
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Doenças do Sistema Digestório
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Outras Neoplasias Malignas
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peritonite Tuberculosa
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Ensaio de Imunoadsorção Enzimática
/
Leucócitos Mononucleares
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Linfócitos T
/
Sensibilidade e Especificidade
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Diagnóstico
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Alergia e Imunologia
/
Testes de Liberação de Interferon-gama
/
Métodos
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
Limite:
Adolescente
/
Adulto
/
Idoso
/
Criança
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Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2013
Tipo de documento:
Artigo