Expression of miR-21 in peripheral blood serum and mononuclear cells in patients with chronic obstructive pulmonary disease and its clinical significance / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 238-243, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-815047
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To explore expression of miR-21 in peripheral blood serum and mononuclear cells of patients with chronic obstructive pulmonary disease (COPD), and to discuss the significance and underlying mechanisms.
@*METHODS@#The subjects were divided into a healthy control group (n=41) and a COPD group (n=49). The miR-21 level was detected by quantitative real-time PCR. The correlations between miR-21 and lung function or forced expiratory volume in one second (FEV1) were analyzed.
@*RESULTS@#The expression levels of miR-21 in the serum and mononuclear cells in the COPD group were significantly elevated compared with those in the healthy group (P<0.05). The expression of miR-21 was correlated with the lung function of COPD patients. The expression level of miR-21 in the COPD patients was positively correlated with FEV1.
@*CONCLUSION@#The upregulation of miR-21 in peripheral blood serum and mononuclear cells of COPD patients may contribute to the pathogenesis of COPD and the severity of this disease.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Leucócitos Mononucleares
/
Volume Expiratório Forçado
/
Doença Pulmonar Obstrutiva Crônica
/
MicroRNAs
/
Reação em Cadeia da Polimerase em Tempo Real
/
Pulmão
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2016
Tipo de documento:
Artigo