Changes in CD40 expression in the pallium and hippocampus in epileptic rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 729-734, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-815279
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the expression of inflammatory molecule CD40 in the pallium and hippocampus of rats after status epilepticus (SE).
@*METHODS@#The expression of CD40 in the pallium, the different areas of hippocampus and the different cells from the lithium-pilocarpine epileptic rats at different time points were examined by immunohistochemistry and double-immunofluorescent labeling.
@*RESULTS@#After SE, CD40 expression was obviously inhibited, especially in hippocampus. CD40 was mainly expressed in the activated microglia. CD40 positive cells reached a peak at the 3rd day and returned to a slightly higher level at the 7th day after SE compared with the level before SE.
@*CONCLUSION@#Elevation of CD40 expression in the activated microglia can promote inflammatory injury of rat's hippocampus, suggesting that CD40 induced-signal pathway is involved in inflammatory injury in the hippocampus after SE.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pilocarpina
/
Estado Epiléptico
/
Imuno-Histoquímica
/
Ratos Sprague-Dawley
/
Microglia
/
Antígenos CD40
/
Epilepsia
/
Hipocampo
/
Lítio
/
Metabolismo
Limite:
Animais
Idioma:
Chinês
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2015
Tipo de documento:
Artigo