Association between CCND1 G870A polymorphism and radiotherapy response in high-risk human papillomavirus-related cervical cancer / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 1205-1209, 2015.
Article
em Zh
| WPRIM
| ID: wpr-815353
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the correlation of cyclin D1 (CCND1) G870A single nucleotide polymorphism (SNP) with radiotherapy response in patients with high risk human papillomavirus (HR-HPV) related cervical cancer.
@*METHODS@#A total of 273 patients with cervical cancer, who were confirmed by histopathology and hybrid capture 2 (HC-2) assay and treated by radiotherapy, were enrolled for this study. The correlation of CCND1 G870A polymorphism with tumor response in patients was assessed.
@*RESULTS@#Compared with patients with AA genotype, the patients with GG genotype and AA genotype showed lower sensitivity to radio-therapy treatment (adjusted ORGA=2.69, 95% CI 1.28-5.67 and adjusted ORGG=3.28, 95% CI 1.47-7.29, respectively), an increase in risks of recurrence/metastasis (adjusted ORGA=2.52, 95% CI 1.12-5.63 and adjusted ORGG=3.95, 95% CI 1.68-9.26, respectively), and shorter recurrence/metastasis-free survival (PGA=0.010 and PGG=0.045).
@*CONCLUSION@#G870A polymorphism is a frequent variation that could be used for evaluate the radio-sensitivity and prognosis for patients with HR-HPV related cervical cancer.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Papillomaviridae
/
Prognóstico
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Radioterapia
/
Virologia
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Neoplasias do Colo do Útero
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Ciclina D1
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Polimorfismo de Nucleotídeo Único
/
Genética
/
Genótipo
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Ano de publicação:
2015
Tipo de documento:
Article