Principles and recent progress in surgical treatment of pancreatic neuroendocrine neoplasms / 中国实用外科杂志

ABSTRACT

Pancreatic neuroendocrine neoplasms(pNENs)are a relatively rare group of heterogeneous tumors with malignant potential originating from pancreatic neuroendocrine cells.Most pNENs grow slowly with an inert biological behavior,and the surgical resection rate and longterm survivalis much better than those of pancreatic ductal adenocarcinoma.Surgery is the only curable way for treatment of pNENs.Surgical approaches should be selected based on the patient's age and physical condition,the grading classification and TNM staging of the tumor,the location of the tumor and its distance to the pancreatic duct,the invasion of surrounding organs,and distant metastasis.Even palliative resection of either the primary tumor or the metastatic lesions may be beneficial for the survival of late staged pNENs patients.