Lagenaria siceraria fruit extract ameliorate fat amassment and serum TNF-α in high-fat diet-induced obese rats
Asian Pacific Journal of Tropical Medicine
; (12): 698-702, 2012.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-819623
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the effects of ethanolic extract of Lagenaria siceraria fruit (ELSF) on fat amassment and serum TNF- α in high-fat diet-induced obese rats.@*METHODS@#The high fat diet induced obese rats were orally treated with orlistat (50 mg/kg) and ELSF (100, 200, 300 mg/kg/day) to the respective treatment groups. The body weight, fasting blood glucose level, lipid profile, serum levels of tumor necrosis factor- α (TNF-α) in rats were measured after 30 days of treatment and compared to the obese control animals.@*RESULTS@#ELSF significantly (P < 0.001) reduced the body weight gain, fasting blood glucose, total cholesterol, triglyceride, total protein and TNF-α.@*CONCLUSIONS@#These encouraging findings suggest that Lagenaria siceraria has excellent pharmacological potential to prevent fat amassment.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Sangue
/
Glicemia
/
Extratos Vegetais
/
Aumento de Peso
/
Tecido Adiposo
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Fator de Necrose Tumoral alfa
/
Ratos Wistar
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Fármacos Antiobesidade
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Cucurbitaceae
Limite:
Animais
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo