In vitro antiplasmodial activity of spiro benzofuran compound from mangrove plant of Southern India
Asian Pacific Journal of Tropical Medicine
; (12): 358-361, 2012.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-819767
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To find out the in vitro antiplasmodial activities of mangrove leaf extracts.@*METHODS@#In vitro antiplasmodial assay was carried out with 13 different mangrove plants. Column chromatography was performed with the most potent Agecerious corniculatum (A. corniculatum) by using various solvent extractions. GC-MS was also preformed with the most potent ethanolic fraction of the A. corniculatum extract.@*RESULTS@#Of the 13 mangroves plants, A. corniculatum showed maximum percentage of parasitemia suppression (94.98 ± 1.16)%. Column chromatography was performed with A. corniculatum with different solvents and the methanolic extract showed maximum percentage (99.73±1.63)% of parasitemia inhibition at 150 μg/mL concentration with the IC(50) value of (29.28±3.23) μg/mL concentration. The results of the GC-MS analysis observed that, the most potent methanolic extract showed maximum retention time (30.687 RT) and the chemical class was identified as Spiro [benzofuran-2(3 H), 1'(3 cyclohexane)-2',3-dione, 7-chloro-4',6] which was responsible for the antiplasmodial activity.@*CONCLUSIONS@#It is concluded from the present study that, the chemical constituents of A. corniculatum collected from Pichavaram mangrove forest can be used as a putative antiplasmodial drugs in future.
Texto completo:
Disponível
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Malária
/
Doenças Negligenciadas
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Parasitologia
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Farmacologia
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Plasmodium falciparum
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Benzofuranos
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Extratos Vegetais
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Cromatografia
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Malária Falciparum
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Folhas de Planta
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Parasitemia
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Testes de Sensibilidade Parasitária
Limite:
Humanos
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo