Antidiabetic activity of aqueous root extract of Merremia tridentata (L.) Hall. f. in streptozotocin-induced-diabetic rats
Asian Pacific Journal of Tropical Medicine
; (12): 175-179, 2012.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-819803
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the antidiabetic effect of aqueous extract of Merremia tridentata (M. tridentata) root (MTRAE) in normal, glucose-loaded hyperglycemic and streptozotocin (STZ)-induced diabetic rats.@*METHODS@#Oral administration of MTRAE at the doses of 50, 100 and 150 mg/kg was studied in normal, glucose-loaded and STZ-diabetic rats. The three doses caused significant reduction in blood glucose levels in all the models.@*RESULTS@#The effect was more pronounced in 100 and 150 mg/kg than 50 mg/kg. MTRAE also showed significant increase in serum insulin, body weight and glycogen content in liver and skeletal muscle of STZ-induced diabetic rats while there was significant reduction in the levels of serum triglyceride and total cholesterol. MTRAE also showed significant antilipidperoxidative effect in the pancreas of STZ-induced diabetic rats. The antidiabetic effect of M. tridentata was compared with glibenclamide, a well known hypoglycemic drug.@*CONCLUSIONS@#The results indicate that aqueous extract of M. tridentata root possesses significant antidiabetic activity.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Extratos Vegetais
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Química
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Administração Oral
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Estreptozocina
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Raízes de Plantas
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Convolvulaceae
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Diabetes Mellitus Experimental
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Relação Dose-Resposta a Droga
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Avaliação Pré-Clínica de Medicamentos
Limite:
Animais
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo