Bioinformatics analysis of breast cancer bone metastasis related gene-CXCR4
Asian Pacific Journal of Tropical Medicine
; (12): 732-738, 2013.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-819975
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To analyze breast cancer bone metastasis related gene-CXCR4.@*METHODS@#This research screened breast cancer bone metastasis related genes by high-flux gene chip.@*RESULTS@#It was found that the expressions of 396 genes were different including 165 up-regulations and 231 down-regulations. The expression of chemokine receptor CXCR4 was obviously up-regulated in the tissue with breast cancer bone metastasis. Compared with the tissue without bone metastasis, there was significant difference, which indicated that CXCR4 played a vital role in breast cancer bone metastasis.@*CONCLUSIONS@#The bioinformatics analysis of CXCR4 can provide a certain basis for the occurrence and diagnosis of breast cancer bone metastasis, target gene therapy and evaluation of prognosis.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Neoplasias Ósseas
/
Neoplasias da Mama
/
Dados de Sequência Molecular
/
Regulação Neoplásica da Expressão Gênica
/
Regulação para Cima
/
Química
/
Alinhamento de Sequência
/
Sequência de Aminoácidos
/
Biologia Computacional
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo
