Cytokine levels in patients with chikungunya virus infection
Asian Pacific Journal of Tropical Medicine
; (12): 631-634, 2013.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-819992
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To investigate cytokine profile in patients with chikungunya virus (CHIKV) infection.@*METHODS@#Twenty eight pairs of serum samples collected from CHIKV infected patients during the outbreak of chikungunya fever in South Thailand in 2008 were obtained. A multiple cytokine assay for detection of 17 cytokines was performed.@*RESULTS@#In the acute stage of CHIKV infection, the patients had significantly higher levels of interleukin-6, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 and tumor necrosis factor alpha than the control (P<0.001, P=0.023, P=0.015, P<0.001 and P=0.024, respectively). When the disease developed to the recovery stage, the patients had significantly lower levels of interleukin-6, granulocyte-macrophage colony-stimulating factor, monocyte chemotactic protein 1 and macrophage inflammatory protein beta than in the acute stage (P<0.001).@*CONCLUSIONS@#This study provides additional information that these cytokines could play roles in pathogenesis of CHIKV infection and could be used as disease biomarkers or drug targets.
Texto completo:
Disponível
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
/
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
Problema de saúde:
Objetivo 8: Surtos, emergências e desastres
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Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
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Febre de Chikungunya
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Doenças Negligenciadas
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
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Tailândia
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Sangue
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Química
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Vírus Chikungunya
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Epidemiologia
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Surtos de Doenças
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Citocinas
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Infecções por Alphavirus
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Soro
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2013
Tipo de documento:
Artigo