Efficiency of HAART in the prevention of mother to children HIV-1 transmission at Saint Camille medical centre in Burkina Faso, West Africa
Asian Pacific Journal of Tropical Medicine
; (12): 991-994, 2012.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-820580
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To evaluate efficiency of HAART in the prevention of mother to child HIV transmission.@*METHODS@#A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre from September 2010 to July 2011. The HIV status of mothers was determined by rapid tests and ELISA. Discordant results were confirmed by real-time PCR. PCR was used to determine HIV status of children born from HIV-positive mothers.@*RESULTS@#Among 1 300 pregnant women tested for HIV, 378 were seropositive. Mothers were predominantly housewives (69.7%), and their mean age was (28.32±0.15) years. The overall prevalence of HIV transmission from mother to child was 4.8% (18/378). This prevalence differed significantly from 0.0% (0/114) to 6.8% (18/264) in children born from mothers under HAART and those with mothers under New Prophylactic Protocol (AZT + 3TC + NVP), respectively (P< 0.01). Children's mortality rate during the medical follow up was 1.3% (5/378). Among 16 women with HIV dubious status by ELISA, the Real Time PCR confirmed 2/16 (12.5%) as HIV positive.@*CONCLUSIONS@#The protocol of prevention of mother to children HIV transmission (PMTCT) is effective. The rate of HIV vertical transmission is significantly reduced. Early diagnosis determined by PCR of children born from HIV-positive mother is necessary and recommended in the context of PMTCT in Burkina Faso. We also found that PCR is an effective tool to confirm HIV status in pregnant women.
Texto completo:
Disponível
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
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ODS3 - Saúde e Bem-Estar
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ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
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ODS3 - Meta 3.2 Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
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Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
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Meta 3.1: Reduzir a mortalidade materna
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Meta 3.2: Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
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AIDS
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Infecções
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fatores Socioeconômicos
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Burkina Faso
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Infecções por HIV
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Reação em Cadeia da Polimerase
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Epidemiologia
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Prevalência
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Estudos Prospectivos
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Transmissão Vertical de Doenças Infecciosas
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Fármacos Anti-HIV
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Terapia Antirretroviral de Alta Atividade
Tipo de estudo:
Guia de prática clínica
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Estudo observacional
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Estudo de prevalência
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Fatores de risco
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Estudo de rastreamento
Aspecto:
Determinantes sociais da saúde
Limite:
Adulto
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Criança
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Feminino
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Humanos
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Gravidez
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2012
Tipo de documento:
Artigo