Serum 25-Hydroxyvitamin D deficiency in Malaysian children with severe atopic dermatitis
The Medical Journal of Malaysia
; : 259-265, 2019.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-822705
Biblioteca responsável:
WPRO
ABSTRACT
@#Background:
Vitamin D deficiency has been shown to be a determinant of disease severity in patients with atopic dermatitis (AD). There is a lack of information on the prevalence of vitamin D deficiency in Malaysian children with AD. The objective of this study was to determine the association of vitamin D deficiency with AD severity, to compare vitamin D deficiency between children with and without AD and to determine prevalence of vitamin D deficiency in children with AD.Methods:
A case-control study to examine serum 25- hydroxyvitamin D [25(OH)D] levels in children with and without AD was done. Serum 25-hydroxyvitamin D [25(OH)D] level was measured by immunoassay. AD severity was evaluated using the SCORing Atopic Dermatitis (SCORAD) index.Results:
The serum levels of 25(OH)D, measured in 135 children with AD was not statistically different from 65 children without AD [median (IQR) 25.2ng/mL (15.45) vs 25.9ng/mL (15.87), p=0.616]. However, serum vitamin D levels were significantly lower in children with severe AD compared to those with mild-to-moderate AD [median (IQR) 16.0ng/mL (19.32) vs 26.3ng/mL (15.56), p=0.021]. The odds of having vitamin D deficiency in children with severe AD was 3.82 times that of children with non-severe AD (95% confidence level 1.13, 12.87).Conclusion:
This study suggests that there is an inverse association between vitamin D level and the severity of AD in Malaysian children.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Idioma:
Inglês
Revista:
The Medical Journal of Malaysia
Ano de publicação:
2019
Tipo de documento:
Artigo