Updates on human equilibrative nucleoside transporter 1 in neoplastic diseases / 国际儿科学杂志

ABSTRACT

The human equilibrative nucleoside transporter 1 (hENT1) is a multi-integrated membrane protein that mediates the transport of nucleosides,nucleobases and nucleoside analogs.It is mainly distributed on the cell membrane in humans.hENT1 maintains the homeostasis of cells and the intracellular concentration of nucleoside drugs through facilitating diffusion,thereby affecting DNA and RNA synthesis,cell signaling,metabolic regulation and rumor chemotherapy.This article reviews the progress in the structure and function of hENT1,the distribution in tumor tissues,the nucleoside analogs response and the prognosis of neoplastic diseases.