Research of inflammatory factors and signaling pathways in knee osteoarthritis / 中国骨伤
China Journal of Orthopaedics and Traumatology
; (12): 388-392, 2020.
Article
em Zh
| WPRIM
| ID: wpr-828285
Biblioteca responsável:
WPRO
ABSTRACT
Knee osteoarthritis is the most common type of arthritis, which is manifested by the deformation and degeneration of articular cartilage and the discomfort of patients with joint pain, which affects the quality of life of patients and aggravates the medical burden of society. The pathogenesis of knee osteoarthritis is very complex. This paper reviews the inflammatory factors and signal pathways involved in knee osteoarthritis. It is found that most of the inflammatory factors involved are interleukin, such as IL-1 β, IL-6, IL-15, IL-17, IL-18, and tumor necrosis factors, such as TNF-α. These inflammatory factors aggravate knee osteoarthritisby activating corresponding pathways and promoting the release of inflammatory mediators. The inflammatory signaling pathways involved in knee osteoarthritis are complex. Notch pathway, Wnt pathway, SDF-1 / CXCR4 pathway, TLRs pathway, MAPKs pathway, hippo Yap pathway, OPG-RANK-RANKL pathway and TGF-β pathway are all involved in the regulation of knee osteoarthritis, and the pathways related to inflammatory mechanism are mainly MAPKs pathway and TLRs pathway. Different signaling pathways can cause the destruction of articular cartilage, promote the apoptosis of chondrocytes, and finally lead to the further imbalance of homeostasis in the knee joint. At the same time, the activation of signal pathway can promote the release of inflammatory factors, so under the cascade reaction of inflammatory factors and signal pathway, knee osteoarthritis is aggravating.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Qualidade de Vida
/
Transdução de Sinais
/
Cartilagem Articular
/
Condrócitos
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Osteoartrite do Joelho
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Interleucina-1beta
Aspecto:
Patient_preference
Limite:
Humans
Idioma:
Zh
Revista:
China Journal of Orthopaedics and Traumatology
Ano de publicação:
2020
Tipo de documento:
Article