Preparation process and structure confirmation of impurity C of rupatifen fumarate / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 530-537, 2020.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-829553
Biblioteca responsável:
WPRO
ABSTRACT
@#The high-purity impurity C was isolated and purified from a new anti-allergic drug, rupatifen, by nucleophilic substitution reaction with bromobutaric acid, and its structure was confirmed by IR, UV, MS, 1H NMR, 13C NMR, DEPT135°,HSQC, HMBC, and 1H-1HCOSY. The preparation process of impurity C in this study was simple and easy to obtain under mild conditions, with the purity of 99.0% and the yield of 25%-30%;and the sample met the target compound by structural confirmation. The preparation process and structure confirmation provided sufficient impurity C reference substance for impurity research of raw materials and preparations of rupatifen fumarate, which laid a solid foundation for quality research of new drugs.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of China Pharmaceutical University
Ano de publicação:
2020
Tipo de documento:
Artigo