Single nucleotide polymorphisms and ossification of posterior longitudinal ligament: Recent progress / 第二军医大学学报
Academic Journal of Second Military Medical University
; (12): 667-669, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-840297
Biblioteca responsável:
WPRO
ABSTRACT
Ossification of the posterior longitudinal ligament (OPLL) is common clinical spinal disorders often occurring in the cervical spine, with the main symptom being nerve compression. The specific mechanism of OPLL remains unclear, but genetic factors, single nucleotide polymorphisms (SNPs), mechanical stimulation, metabolism abnormality might be involved in the etiology of the disease. Multiple genetic and environmental factors may contribute to the development of OPLL. OPLL has prominent genetic characteristic, and it is associated with SNPs of several genes. Here we review the SNPs of several genes (COL11A2, BMP-2, TGF-β1, TGF-β3, NPPS, COL6A1 and Runx2) which contribute to the development of OPLL, hoping to lay a foundation for future study.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo