Relationship of GSTP1, RASSF1A polymorphisms and environmental agent with susceptibility to prostate cancer: A case-control study / 第二军医大学学报
Academic Journal of Second Military Medical University
; (12): 12-17, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-840390
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To investigate relationship of GSTP1, RASSF1A polymorphisms and environmental agent with susceptibility to prostate cancer (Pca).Methods:
The GSTP1 and RASSF1A genotypes were determined by TaqMan/MGB Probe Technology in 103 patients with Pca and 103 normal controls. Multivariate logistic regression model was used to assess the association of smoking, alcohol drinking, tea drinking, weekly pork and beef consumption, and the genetic polymorphisms with the susceptibility to Pca, while taking into consideration of the environmental agent.Results:
The frequencies of the GSTP1 AA, AG and GG genotypes were 66.02%, 22.33%, and 11.65% in patients with Pca and 67.96%, 29.13% and 2.91% in controls, respectively, with significant difference found between the two groups (X2 = 6.35, P = 0.04). The frequencies of RASSF1A CC, CA and AA genotypes were 88.34%, 5.83%, and 5.83% in patients with Pca, and 85.44%, 12.62%, and 1.94% in the controls, respectively, with no significant difference found between the two groups (X2 = 4.63, P = 0.10). Multivariate analysis showed a decreased risk in those who had a tea drinking history (OR = 0.40, 95% CI, 0.19-0. 82) and an increased risk in those who had a smoking history (OR = 3.02, 95% CI, 1.44-6. 32).Conclusion:
Our results indicate that GSTP1, RASSF1A polymorphisms are not associated with Pca susceptibility in Chinese Han nationality. Smoking is the risk factor of Pca, and tea drinking is a protective factor against Pca.
Texto completo:
Disponível
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
/
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.5 Prevenção e tratamento do consumo de substâncias psicoativas
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
/
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
/
Álcool
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo