Effects of penetration enhancers on skin permeation behavior of fluoxetine hydrochloride in vitro / 第二军医大学学报
Academic Journal of Second Military Medical University
; (12): 1252-1254, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-841020
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To study the effects of penetration enhancers and their combinations on the transdermal delivery of fluoxetine hydrochloride and to discuss the feasibility of transdermal administration of drugs.Methods:
The penetration rate of fluoxetine hydrochloride through rat skin in vitro was measured using Valia-Chien diffusion cells and high pressure liquid chromatography was used for analysis.Results:
Penetration enhancers, such as Azone, N-methyl-2-pyrrolidone(NMP), oleic acid, and their combinations all had peneration enhancing effect except for propylene glycol(PG). Azone combined with PG or NMP had the most potent enhancing effect.Conclusion:
Satisfactory penetration of fluoxetine hydrochloride through rat skin can be obtained by correct combination of enhancers.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo