Development of antibody used by antibody-Drug conjugates / 国际药学研究杂志

ABSTRACT

Antibody drug conjugates (ADC), the new generation of antibody technology, combine the target-specificity of mon-oclonal antibody (mAb) and the highly active cell-killing drugs, taking advantages of the best characteristics out of both components. ADC consist of three different components antibody, linker and cytotoxic drugs (also frequently referred as payload).The antibody component, the vector to selectively deliver a highly toxic drug to the cancer cell, plays an important role in the development of the ideal ADC. This paper reviews the development and current situations, features, types and target selection of the naked antibody, and the development of different targets antibodies existing at present.