Application of systematic biology technology in research of traditional Chinese medicine based on overall research / 中草药

ABSTRACT

Traditional Chinese medicine is the treasure of China, which has played an indelible role in the process of fighting against diseases. Under the background of times of building Healthy China, how to play the unique advantages of traditional Chinese medicine in the disease prevention and treatment is the focus of attention. Traditional Chinese medicine has the characteristics of "multi-component, multi-target, and overall regulation", and it's not enough to reveal its internal essence only by the way of "local concept", so the research thinking of "overall concept"is imperative. System biology, a research technology, which understands the organism from a holistic perspective and coincides with the way of "overall concept"of traditional Chinese medicine. Therefore, the research strategy of traditional Chinese medicine based on system biology with highly feasible. In this paper, the application of system biology technologies, such as genomics, transcriptome, proteomics, metabonomics, microbiomics, omics combination and network pharmacology technology, in the research of ingredients, pharmacology and toxicology, identification, cultivation and genetic breeding of traditional Chinese medicine was reviewed, in order to provide reference for the further application of system biology strategy in the research of traditional Chinese medicine, based on the idea of "overall concept".