Effect of cytokines and platelet-rich plasma on tendon derived stem cells

ABSTRACT

BACKGROUND:

Tendon derived stem cells exist in the tendon and have unique functions for tendon repair. Different cytokines have different effects on the proliferation and differentiation of tendon derived stem cells. Platelet-rich plasma refers to the blood product obtained from the whole blood through gradient centrifugation and stratification, which contains a variety of cytokines that could help to promote the regeneration of ligaments and tendons.

To investigate the latest progress of effects of cytokines and platelet-rich plasma on proliferation and differentiation of tendon derived stem cells.

Using “tendon derived stem cells, tendon stem/progenitor cells, tendon stem cell, platelet-rich plasma, ligament injury” as keywords in English and “tendon derived stem cells, platelet-rich plasma, ligament injury” in Chinese, the first author searched PubMed, CNKI, and Wanfang for relevant articles published from 2007 to 2019. Literature unrelated to the purpose of the study and repetitive literature were excluded, and 83 articles that meet the criteria were included for review. RESULTS AND

Tendon derived stem cells are ideal cells for the treatment of tendon injury in cell transplantation. Its proliferation and differentiation are influenced by cytokines. Platelet-rich plasma contains a large number of cytokines, which can stimulate the proliferation and differentiation of tendon derived stem cells and have the potential to become a carrier of cell transplantation. Exploring the relationship between cytokines and proliferation and differentiation of tendon stem cells will provide a new approach for the clinical application of tendon derived stem cells.