Mechanism of action of energy metabolism molecule sirt1 in improving bone metabolism of type 2 diabetes / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
; (53): 276-281, 2020.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-848097
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Energy metabolism regulates type 2 diabetes bone metabolism is a hotspot in the field of life medicine. Long-term disorders of energy metabolism such as sugar and lipids lead to insulin resistance, which triggers type 2 diabetes. Silent information regulator 1 (SIRT1), a nicotinamide adenine dinucleotide- dependent histone deacetylase, is a key factor regulating energy metabolism and is involved in bone metabolism, gene transcription, cellular senescence, apoptosis and pyroptosis.OBJECTIVE:
To analyze the recent literature on the mechanism of action of SIRT1 in exercise-improving bone metabolism, and to investigate its current status and research progress.METHODS:
Databases of PubMed and CNKI were retrieved. The keywords were “SIRT1, exercise, type 2 diabetes, bone formation, bone resorption” in Chinese and English, respectively. RESULTS ANDCONCLUSION:
(1) The differentiation and function of osteoblasts and osteoclasts and the metabolic balance are the key to ensure the homeostasis of bone metabolism. In the event of a disorder, the morphological structure of the bone tissue will be degraded, which is also an important mechanism for the occurrence of osteoporosis in type 2 diabetes complications. (2) Energy metabolism disorder is critical for triggering type 2 diabetes. SIRT1, as a key factor regulating energy metabolism, can mediate osteoblast and osteoclast differentiation and function through Wnt and transforming growth factor-)} pathways. (3) Recently, exercise has been shown to significantly improve the energy metabolism and bone metabolism of type 2 diabetes. Based on the osteoblasts and osteoclasts, the current researches at home and abroad are reviewed to explore the mechanism of SIRT1 in the improvement of type 2 diabetes bone metabolism.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Tissue Engineering Research
Ano de publicação:
2020
Tipo de documento:
Artigo