Research progress in long non-coding RNA and the diagnosis, treatment and prognosis of colorectal cancer / 肿瘤

ABSTRACT

Long non-coding RNAs (LncRNAs) is a group of non-coding RNAs with length exceeding 200 bp that can not code complete protein. Dysregulation of LncRNAs is involved in various molecular mechanisms and has a significant role in occurrence and development of tumor. Colorectal cancer (CRC) is one of the most common cancer. The screening, diagnosis and personalized treatment of CRC are urgent to be improved. Dysregulation of LncRNAs is related to tumor stage and clinicopathological features of CRC, which have been suggested to be used as novel potential biomarkers for diagnosis, prognostic prediction and treatment of CRC. This review summarizes the advances in expression and role of LncRNAs in CRC.