Incidence and survival rates of primary renal cell carcinoma in residents in Pudong New Area in Shanghai, 2002-2011 / 肿瘤

ABSTRACT

Objective: To investigate the incidence and survival rates of primary RCC (renal cell carcinoma) in residents in Pudong New Area in Shanghai. Methods: The residents in Pudong New Area in Shanghai were recruited in this study during the period 2002-2011. The standardized morbidity and mortality of primary RCC were calculated by world standard population. The survival of primary RCC patients according to gender, resident district, TNM staging and surgical operation was analyzed by Kaplan-Meier method and COX regression analysis. Results: Among 1 905 new cases of primary RCC occurring during 2002-2011, 1 234 were males and 671 were females. The age-standardized incidence rate in males (5.17/100 000 person-year) was higher than that in females (3.07/100 000 person-year). In 697 cases of RCC-related death, 453 were males and 244 were females. The age-standardized mortality in males (1.88/100 000 person-year) was higher than that in females (0.92/100 000 person-year). The one-, two-, three-, four-, and five-year survival rates of patients with primary RCC were 74.75%, 69.84%, 66.38%, 63.40% and 61.44%, respectively. There was a statistically significant difference in overall survival between central city vs other areas (P = 0.040), early stage vs advanced stage (P < 0.001), and having surgical operation vs not having surgical operation (P < 0.001). Advanced stage and not having surgical operation were independent risk factors in patients with primary RCC (P < 0.001). Conclusion: The incidence and mortality rates of primary RCC in males and in central city were significantly higher than those in females and in other areas in residents in Pudong New Area in Shanghai, 2002-2011, respectively. Early diagnosis of primary RCC and performance of surgery can significantly improve the prognosis of patients. Copyright © 2013 by TUMOR.