Expression of hSTC-1 gene in peripheral blood and its correlation with micrometastases of breast cancer / 肿瘤
Tumor
; (12): 977-980, 2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-849461
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To detect the expression of human stanniocalcin-1 (hSTC-1) mRNA in peripheral blood and tumor tissues of breast cancer patients, determine micrometastases in peripheral blood, and study the relationship between the micrometastases and malignant degree of breast cancer.Methods:
The expression of hSTC-1 mRNA in peripheral blood and breast cancer tissues was detected by RT-PCR. The expression of estrogen receptor (ER), progesterone receptor (PR), and vascular endothelial growth factor (VEGF) in breast cancer tissues were detected by immunohistochemical method.Results:
Expression of hSTC-1 mRNA was identified in breast cancer tissues from 28 of 30 patients (93.3%) and in peripheral blood from 19 of 51 patients (37.3%). Expression of hSTC-1 mRNA was not detected in the peripheral blood from 17 women without breast cancer. Expression of hSTC-1 mRNA in the peripheral blood significantly correlated with multiple clinicopathological factors (P < 0.05), including tumor size, metastasis of lymph nodes, TNM stage, and the expression of ER and VEGF.Conclusion:
The expression of hSTC-1 mRNA in the peripheral blood of breast cancer patients suggests the occurrence of micrometastasis. It significantly correlates with multiple clinicopathological factors which determined the prognosis of breast cancer. So hSTC-1 is proposed as a new marker for detecting micrometastasis of breast cancer in the peripheral blood.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Tumor
Ano de publicação:
2007
Tipo de documento:
Artigo