Study of the anti-fatigue effects of amino acids and vitamins / 解放军医学杂志

ABSTRACT

Objective To investigate the anti-fatigue effects of amino acids and vitamins on rats after exhaustive exercise. In addition, the current research might provide a theoretical foundation for the future development of new anti-fatigue nutritional supplements. Methods Thirty-six male SD rats were randomly divided into three groups after adaptive swimming. Each group consisted of 12 rats, namely amino acids and vitamins capsule group (capsule group), control with bland water group (control group), and amino acid and fructose beverage group (granules group). Exhaustion was produced by non-load swimming. After 14 days of feeding with different beverages, the exhaustion time of swimming was recorded, and then all rats were killed to measure concentrations of muscle and hepatic glycogen, and contents of serum β-endorphin (β-EP), lactic acid (LA), lactate dehydrogenase (LDH), and creatine kinase (CK). Results The swimming time and the levels of the muscle and hepatic glycogen in the capsule and granules groups were longer or higher than those in the control group (P0.05). Conclusion Compound amino acids and vitamins can delay the occurrence of exhaustion after swimming in rats, increase hepatic and muscle glycogen contents, and decrease the generation of various metabolites during fatigue exercises, and hence giving anti-fatigue effects.