Preparation of curcumin thermoresponsive nanogels and their characteristics / 中草药

ABSTRACT

Objective: To prepare curcumim thermoresponsive nanogels and study its release characteristics in vitro. Methods: Poly (N-isopropyl acrylamide) (PNIPAm) thermoresponsive nanogels were synthesized by emulsion polymerization method, and then curcumin loaded-PNIPAm nanogels were prepared. The characteristics of PNIPAm nanogels, the drug loading, and the drug release in vitro were investigated. Results: Atomic force micriscopy (AFM) observation showed that PNIPAm nanogels were spherical in shape with homogenous size. Moreover, PNIPAm No. 5 showed a high drug loading (27%). In vitro release study revealed that the 24 h accumulative in vitro release reached 75.2%. Conclusion: The method used to prepare curcumin thermoresponsive nanogels is simple. It is expected to become a novel vehicle potentially nanoparticle drug delivery system of curcumin.