Antitumor, analgesic, and anti-inflammatory effects of Ornithogalum caudatum extracts / 中草药

ABSTRACT

Objective: To investigate the antitumor, analgesic, and anti-inflammatory effects of Ornithogalum caudatum extract (OCE). Methods: The MFC, HepG-2, and S180 tumor-bearing mice models were established, and the tumor inhibitory rate of OCE was calculated; The analgesic effect of OCE was observed by acetic acid writhing test of mice; The anti-inflammatory effect of OCE was observed in xylene-induced ear edema model of mice. Results: OCE (5.0 and 2.5 g/kg) could effectively inhibit the growth of solid tumors in tumor-bearing mice in a dose-dependent manner (P < 0.05, 0.001); Compared with the model group, OCE (5.0 and 2.5 g/kg) could significantly inhibit the writhing response (P < 0.05, 0.001) and xylene-induced ear edama (P < 0.05, 0.01). Conclusion: OCE has certain antitumor, analgesic, and anti-inflammatory effects, suggesting they may be worth further investigation.