Effects of different interval intracerebroventricular administration of brain-derived neurotrophic factor on hypoxic ischemic encephalopathy in neonatal rats / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 204-207, 2002.
Article
em Zh
| WPRIM
| ID: wpr-857464
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ABSTRACT
AIM: To observe the effects of different interval administration of exogenous brain derived neurotrophic factor (BDNF) on hypoxic-ischemic encephalopathy in neonatal rats. METHODS: BDNF (0.5 μg) was microinjected intracerebroventricularly at 0, 1 and 4 h after the hypoxic-ischemic encephalopathy in 7 d neonatal Sprague-Dawley rats undergone by ligation of left common carotid artery followed by a 2.5 h inhalation of humidified 8% 02 + 92% N2 at 37°C immediately after the injury, respectively. Changes of brain edema, levels of malondialehyde (MDA) and neuronal apoptosis at the left cortex and hippocampus were investigated 24 h after the injury. RESULTS: The most prominent effect of BDNF was seen in 0 h group with a marked decreases in brain edema and levels of MDA and a significantly alleviated neuronal apoptosis while it was lowered obviously when administered at 4 h after the insult. CONCLUSION: BDNF exerts a prominent protective effect on hypoxic-ischemic encephalopathy in neonatal rats when given as early as possible after the injury rather than later administration.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Pharmacological Bulletin
Ano de publicação:
2002
Tipo de documento:
Article