Effects of nitric oxide on experimental hepatic fibrosis in rats / 中国药理学通报

ABSTRACT

AIM: To study the role of nitric oxide (NO) in the pathogenesis of hepatic fibrosis. METHODS: To establish the model of hepatic fibrosis in rats and treated with L-Arg (preNO) and L-NNA (NOS inhibitor). The degree of hepatic fibrosis, the levels of HA, AST, ALT determined with histology, radioimmunoassay, autochemol-analysis, respectively. NO and NOS were also determined. RESULTS: The degree of hepatic fibrosis, the levels of AST, ALT and HA in L-Arg group were all lower than those in hepatic fibrosis control group. While the levels of HA and AST in L-NNA group were higher than that in hepatic fibrosis control group. CONCLUSION: NO has the function of protecting liver cells and anti-hepatofibrosis liver fibrosis induced by CCl4 in rats.