Research progress in regulatory effect of sulforaphane on diabetes and fatty liver disease / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
; (6): 628-632, 2020.
Article
em Zh
| WPRIM
| ID: wpr-857516
Biblioteca responsável:
WPRO
ABSTRACT
The intervention of sulforaphane can reduce the risk of diabetes and its complications. It is mainly achieved by regulating nuclear factor erythroid-2-related factor 2 (Nrf2) to inhibit endothelial cell activation and improve high density lipoprotein levels. In addition, sulforaphane can bring about a marked improvement on fatty liver disease by regulating lipid metabolism. Its important pathways include the regulation of peroxisome proliferators-activated receptors y (PPARy), hormone-sensitive triglyceride lipase (HSL) and AMP-activated protein kinase (AMPK) regulation promotes lipolysis. In summary, further exploration of the mechanism of action of plant-derived functional ingredients of sulforaphane may be the key to preventing and treating diabetes and fatty liver disease.
Texto completo:
1
Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Pharmacology and Toxicology
Ano de publicação:
2020
Tipo de documento:
Article