Research advances in regulation mechanism of ferroptosis and its role in liver diseases / 中国药理学与毒理学杂志

ABSTRACT

Ferroptosis is a newly discovered way in which cells die, which is essentially different from classical apoptosis and necrosis. Ferroptosis is caused by abnormal increase in iron levels in cells, resulting in an imbalance of redox, lipid peroxidation in the cell membrane, and eventually cell membrane rupture, leading to cell death. Iron metabolism and active oxygen metabolism are considered to be the central links of ferroptosis. Ferroptosis involves many physiological and pathological processes, including cancer cell death, neurotoxicity, ischemia/reperfusion injury and T cell immunity. More and more studies have shown that iron overload and accumulation of lipid reactive oxygen species occur to different degrees during the occurrence and development of various liver diseases. Ferroptosis can affect the progress of liver diseases by regulating intracellular iron levels and lipid peroxidation. Therefore, regulating ferroptosis may be a new strategy for treating liver diseases. This article reviews recent advances in ferroptosis and its role in liver diseases, providing a theoretical basis for exploring treatments for liver diseases.