Effect of solvent pH on properties and clinical use of four drugs in gynecology and obstetrics / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 2175-2194, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-858883
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To investigate the effect of solvent pH on the physical/chemical properties and clinical use of four drugs commonly used in gynecology and obstetrics, including aminophylline, ambroxol, labetalol and ritodrine, through simulation and evidence-based evaluation to provide theoretical guidance and quantitative reference for clinical use.METHODS:
By searching PubMed compound and Martindale The Complete Drug Reference, the physical/chemical and clinical information of the four drugs were obtained. The logP, pKa, logD, and solubility were simulated using ACD/LAB 6.0 software.RESULTS:
The solvent pH had effects on the logD and solubility of the four drugs to a certain degree in an exponential manner. The four drugs are compatible with dextrose injection or 0.9% sodium chloride injection, but special care needs to be taken in the clinical use.CONCLUSION:
Solvent pH has influence on the dissolution balance of the four drugs. Simulation of the physical/chemical properties of drugs will provide theoretical guidance and reference for clinicians with more detailed information.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Guia de prática clínica
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2016
Tipo de documento:
Artigo