Optimization for preparation process of fanhuncaoin dry powder for inhalation / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 1241-1244, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-859046
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To optimize the preparation process conditions of fanhuncaoin dry powder for inhalation by orthogonal design.METHODS:
Fanhuncaoin dry powder was prepared by spray-drying method. Following spray-drying, particle size analysis was performed by laser diffraction. Resultant powders were characterized using scanning electron microscopy. The aerosolisation performance was determined using twin-stage liquid impinger. And moisture content was examined by thermogravimetric analysis. The preparation process conditions were optimized with orthogonal design combined with multi-index test. The powder yield, aerodynamic diameter, moisture content and respirable fraction were used as indices for orthogonal design.RESULTS:
The results of optimized process parameters were confirmed with atomization pressure of 210 kPa, feed flow rate of 9.1 mL·min-1, aspiration speed of 0.6 m3·min-1 and inlet temperature of 130℃. As a result, 51.19% yield, 2.92 μm aerodynamic diameter, 4.18% moisture content and 54.45% respirable fraction are obtained by the optimal process conditions.CONCLUSION:
Orthogonal design combined with multi-index test can be used to optimize the preparation process of fanhuncaoin dry powder for inhalation.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2016
Tipo de documento:
Artigo