Preparation of Lutein Thermosensitive in situ gels for ophthalmic use and the in vitro release / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 1880-1884, 2015.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-859314
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To optimize the formulation of the lutein thermosensitive in situ gels by using central composite design-response surface methodology, and study the drug release in vitro.METHODS:
Gelation temperature was served as the indicator. The influences of the amounts of Poloxamer 407 and Poloxamer 188 on the gelation temperature were investigated. Central composite design-response surface method was used to optimize the prescription. The drug release profile of the preparation was investigated with a membrane-less dissolution model.RESULTS:
The amounts of Poloxamer 407 and Poloxamer 188 had quantitative relationships with the gelation temperature. The optimum prescription was as follows the mass concentration of P407 was 0.21 g · mL-1, and the mass concentration of P188 was 0.03 g · mL-1. The dissolution and drug release of the gels followed zero-order kinetics equation.CONCLUSION:
Central composite design-response surface methodology can be applied to optimize the formulation of the lutein thermosensitive in situ gels.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2015
Tipo de documento:
Artigo