Therapeutic effects and mechanisms of total flavonoids of Chrysanthemum indicum on liver fibrosis in rats / 中国药学杂志

ABSTRACT

OBJECTIVE: To observe therapeutic effects and mechanisms of total flavonoids of Flos Chrysanthemum indicum (TFC) on liver fibrosis in rats. METHOD: The model of rat liver fibrosis was adopted which was induced by CCl4 injection. The effects of FFC were observed on the levels of serum ALT, AST, HA, LN, PC III and C IV in rats with liver fibrosis, and on liver histopathological 'hanges as well as collagen hyperplasia formation in liver tissue. The gene expression of TGF-β1 was detected by RT-PCR. RESULTS: Compared with the model group, TFC treatment significantly reduced ALT, AST, HA, LN, PC III and CIV content in serum, liver listology in the TFC treated rats was also improved. Moreover TFC could decrease the expression of TGF-beta;1. CONCLUSION: TFC Has a significant curative effect on the liver fibrosis rats, its mechanism probably be related to decrease the expression of TGF-beta;1.