Research progress in receptor binding assay by mass spectrometry / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 1244-1248, 2013.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-860283
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To explain that receptor-ligand binding assay is an important drug screening method, which can quickly and inexpensively study the interactions between the targeted receptor and the potential ligands in vitro and provide information about the relative binding affinity of ligand-receptor.METHODS:
The correlative literature and abroad were collected and analyzed. RESULTS ANDCONCLUSION:
The concept of MS binding assay based on mass spectrometric quantification of nonlabeled markers represents a promising alternative to conventional radioligands binding without inherent drawbacks. The technique will play an important role in the design and screening of receptor-targeting pharmaceuticals.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2013
Tipo de documento:
Artigo