Simultaneous determination of ligustilide, senkyunolide I and other six components in Shunaoxin dropping pills by UPLC-Q-TOF-MS / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 216-219, 2013.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-860492
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To establish an LC-MS method for simultaneous determination of six compounds (uridine, guanosine, ferulic acid, ligustilide, senkyunolide I and II in Shunaoxin dropping pills.METHODS:
The analysis was performed on a Waters Acquity BEH C18 column (2.1 mm × 100 mm, 1.7 μm) with the mixture of acetonitrile-water-formic acid as the mobile phase, and the flow rate was 0.4 mL · min-1; the PDA detection wavelength was 190-400 nm; the column temperature was room temperature (30°C).RESULTS:
The linear ranges for uridine, guanosine, ferulic acid, ligustilide, senkyunolide I and H were 10.31-206.24, 3.28-65.52, 6.36-127.24, 8.24-164.88, 10.18-200.52, and 3.14-62.72 μg · mL-1, respectively. The average recoveries were between 99%-101% (n=6).CONCLUSION:
This method is simple, accurate and reliable to determine the contents of the six compounds in Shunaoxin dropping pills for the quality control.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2013
Tipo de documento:
Artigo