Synthesis and cytotoxicity study of N-benzyl-3, 5-bis(arylmethylene)-4-piperidones / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 1588-1591, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-860613
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To synthesize a kind of novel cytotoxin with multi-drug-resistance reverting properties and study their cytotoxicity.METHODS:
The target compounds were obtained from N-benzyl-4-piperidones and benzaldehyde derivatives on the condition of 20°C, 7-8 h, taking dry hydrogen chloride as catalyst, using aldol condensation reaction, inspected by TLC and purified through recrystallization.RESULTS:
Five N-benzyl-3, 5-bis(arylmethylene)-4-piperidone derivatives were synthesized. The yield was over 49%. Their structures were characterized by 1H-NMR, ESI-MS with melting points. The data of cytotoxicity was obtained.CONCLUSION:
The synthetic route is convenient and efficient; The compounds had good inhibiting activity for a few kinds of tumor cells. Copyright 2012 by the Chinese Pharmaceutical Association.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2012
Tipo de documento:
Artigo