Study on preparation technology of compound Danshen pulsatile release pellets / 中国药学杂志
Chinese Pharmaceutical Journal
; (24): 908-914, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-860721
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To prepare compound Danshen adhesion pulsatile release pellets.METHODS:
Different coating materials were used. Swelling layer, controlled-release layer and adhesive layer were packed on drug-containing pellets from inside to outside. The coating effect on the dissolution was studied. The coating formulation was optimized. The adhesiveness of the pellets was e-valuated.RESULTS:
The release delay and rate were affected by the materials of swelling layer, controlled-release layer and adhesive layer, the weight of coating layer, and the type and quantity of plasticizer.CONCLUSION:
With the best coating prescription, a delay of 4.5 h in drug release was reached in simulated changing human gastrointestinal pH environment. The cumulative release reached more than 80% 1.5 h post the release lag, indicating a pulsatile release effect.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Pharmaceutical Journal
Ano de publicação:
2012
Tipo de documento:
Artigo