Clinical study of self-made Chaimu-Xingnao Decoction combined with rehabilitation training in the treatment of cognitive dysfunction after stroke / 国际中医中药杂志

ABSTRACT

Objective:To evaluate the clinical effects of self-made Chaimu-Xingnao Decoction combined with rehabilitation training in the treatment of cognitive dysfunction after stroke. Methods:A total of 82 stroke patients with cognitive dysfunction who met the inclusion criteria in Haikou Hospital of Traditional Chinese Medicine from January 2015 to December 2018 were divided into two groups according to random number table method, 41 in each group. The control group was treated with rehabilitation training on the basis of routine treatment, and the observation group was given self-made Chaimu-Xingnao Decoction on the basis of the control group. Both groups were treated for 12 weeks. The cognitive function of the patients was evaluated by neurobehavioral cognitive status examination (NCSE). The whole high blood viscosity, whole low blood viscosity, plasma viscosity, hematocrit and fibrinogen were detected by automatic hemorheology tester, and the levels of nerve growth factor (NGF) and neurotrophic factor (NTF) were detected by ELISA. The clinical efficacy was evaluated. Results:The total clinical effective rate of the observation group was 90.2% (37/41), which was significantly higher than 70.7% (29/41) of the control group, and the difference was statistically significant ( χ2=4.970, P=0.026). After treatment, the NCSE score in the observation group was significantly higher than that of the control group ( t=3.689, P<0.01), the whole high blood viscosity, whole low blood viscosity, plasma viscosity, hematocrit and fibrinogen in the observation group were significantly lower than those in the control group ( t values were 12.406, 14.638, 10.947, 12.546 and 8.451, respectively, all Ps<0.001), the serum NGF (119.82 ± 16.73 pg/ml vs. 93.31 ± 15.20 pg/ml, t=7.510) and NTF (5.58 ± 0.59 ng/ml vs. 4.01 ± 0.52 ng/ml, t=12.783) level in the observation group were significantly higher than those in the control group ( P<0.01). There were no serious adverse reactions during treatment in both groups. Conclusions:Self-made Chaimu-Xingnao Decoction combined with rehabilitation training can improve the hemorheology index, regulate the level of nerve cell factor and improve the clinical effect of patients with cognitive dysfunction after stroke.